2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-171003
    SOBRAC 362678-28-2 98%
    SOBRAC is an irreversible inhibitor of acid ceramidase (Ceramidase) with a Ki of 29.7 nM, and it's also a derivative of the acid ceramidase inhibitor SABRAC (HY-165070).
    SOBRAC
  • HY-171016
    D-Biopterin 13039-62-8 98%
    D-Biopterin is an enantiomer of L-Biopterin (HY-102015). L-Biopterin, a pterin derivative, is a NO synthase cofactor.
    D-Biopterin
  • HY-171024
    Cannabinol ethyl 99623-70-8 98%
    Cannabinol ethyl (CBN-C2) is structurally similar to known phytocannabinoids.
    Cannabinol ethyl
  • HY-171025
    Cannabiorcol 19825-73-1 98%
    Cannabiorcol (Cannabinol C1) is structurally similar to known phytocannabinoids.
    Cannabiorcol
  • HY-171028
    3-Hydroxy desalkylflurazepam 17617-60-6 98%
    3-Hydroxy desalkylflurazepam is a benzodiazepine with potential sedative and anxiolytic effects.
    3-Hydroxy desalkylflurazepam
  • HY-171031
    TFGF-18 2222662-20-4 98%
    TFGF-18 is a GSK-3β inhibitor (IC50: 0.59 μM). TFGF-18 inhibits LPS-induced microglia activation and proinflammatory mediators release via inhibiting GSK-3β and downstream p65/NF-κB signaling. TFGF-18 inhibits neuronal apoptosis and oxidative stress, inhibits expressions of Bax, caspase3 and cleaved-caspase3 and increases the expression of Bcl-2. TFGF-18 has neuroprotection effect, inhibit neuroinflammation and attenuates cognitive impairment.
    TFGF-18
  • HY-171033
    ASM-IN-3 2342576-75-2 98%
    ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats.
    ASM-IN-3
  • HY-171037
    Prostaglandin Bx 39306-29-1 98%
    Prostaglandin Bx (PGBx) is an oligomer of PGB1 and 15-keto-PGB, which exhibits mitochondrial protective efficacy. Prostaglandin Bx promotes the neurological recovery in rabbits ischemic spinal cord injury model, and maintains the integrity of the gastric mucosa through inhibition of gastric acid secretion in rat gastric ulcer model.
    Prostaglandin Bx
  • HY-171182
    D3017 130403-18-8 98%
    D3017 is the main metabolite of D2624, which has oral bioactivity and anti-convulsant effects. D3017 ED50 value is 1.5 mg/kg in mice, and it can be used for research on severe generalized tonic-clonic seizures (grand mal) and complex partial epilepsy.
    D3017
  • HY-171449
    SCH 211803 331765-50-5 98%
    SCH 211803 is a selective antagonist of the M2 muscarinic receptor. SCH 211803 is promising for research of cardiovascular and nervous system diseases.
    SCH 211803
  • HY-171460
    Win 45164 83880-39-1 98%
    Win 45164 is an orally active glucocorticoid receptor (Glucocorticoid Receptor) ligand with the activity of inhibiting the pituitary - adrenal axis. It can promote liver glycogen deposition and thymus involution in adrenalectomized male rats. Meanwhile, Win 45164 has anti - inflammatory effects. It can be used in the research of inflammatory and neurological diseases.
    Win 45164
  • HY-171462
    SMW139 2133010-38-3 98%
    SMW139 is a selective allosteric antagonist of P2X7 receptor, with a Ki value of 32 nM for human P2X7R. The half-life of SMW139 in rat liver microsomes is 47 minutes. SMW139 can be used for inflammation, Alzheimer’s disease, multiple sclerosis study.
    SMW139
  • HY-171471
    SKF 10810 22196-65-2 98%
    SKF 10810 is a GABAA receptor antagonist with an EC50 of 4.3 μM. By blocking GABAergic inhibition of the brain's reward pathways, SKF 10810 may exert antidepressant effects. SKF 10810 can be used for research in neurological disorders.
    SKF 10810
  • HY-171472
    A-86929 171961-95-8 98%
    A-86929 is a highly potent and selective dopamine D1 receptor agonist with a pKi value of 7.3. In the 6-OHDA (HY-B1081)-induced unilateral nigrostriatal lesion rat model, A-86929 significantly induces rotational behavior. It also improves motor function in the MPTP (HY-15608)-induced Parkinson's disease marmoset model. Additionally, A-86929 demonstrates potential therapeutic value in reducing cocaine-seeking behavior in rats and reversing Haloperidol (HY-14538)-induced cognitive deficits in rhesus monkeys. A-86929 can be used for research in neurological disorders.
    A-86929
  • HY-172000
    (S)-3-Keto sphinganine (d18:0) hydrochloride 25515-53-1 98%
    (S)-3-Keto sphinganine (d18:0) hydrochloride is an intermediate in the biosynthesis of C18-Ceramide (HY-100355).
    (S)-3-Keto sphinganine (d18:0) hydrochloride
  • HY-172004
    N-Desmethyl asenapine 128915-56-0 98%
    N-Desmethyl asenapine is a metabolite of Asenapine (HY-10121). Asenapine, an atypical antipsychotic agent, is an antagonist of serotonin receptors, adrenoceptors, dopamine receptors and histamine receptors.
    N-Desmethyl asenapine
  • HY-172005
    10,11-Dihydroxycarbamazepine 35079-97-1 98%
    10,11-Dihydroxycarbamazepine is a metabolite of the anticonvulsant Carbamazepine (HY-B0246). Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker.
    10,11-Dihydroxycarbamazepine
  • HY-172010
    4-Hydroxyphenylpropionylglycine 3850-43-9
    4-Hydroxyphenylpropionylglycine is a metabolite of the conditionally essential amino acid Tyrosine (HY-N0473).
    4-Hydroxyphenylpropionylglycine
  • HY-172026
    N-Nitroso clonidine 148950-49-6 98%
    N-Nitroso clonidine, a nitrosamine, is a metabolite of Clonidine (HY-12721). Clonidine is an alpha 2-adrenergic agonist.
    N-Nitroso clonidine
  • HY-172029
    3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride 2748289-38-3 98%
    3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride is an analog of Pyrovalerone. Pyrovalerone inhibits the dopamine transporter (DAT)，serotonin transporter (SERT)，and the norepinephrine transporter (NET).
    3,4-Methylenedioxy pyrovalerone metabolite 2 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity